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Zacks Company Profile for DURECT Corporation (DRRX : NSDQ)

• Company Description    Durect Corp. is pioneering the treatment of chronic diseases and conditions by developing and commercializing pharmaceutical systems to deliver the right drug to the right place in the right amount at the right time. Its pharmaceutical systems combine engineering innovations and delivery technology from the medical device and drug delivery industries with its proprietary pharmaceutical and biotechnology drug formulations. Number of Employees: 21

• Price / Volume Information    Yesterday's Closing Price: $0.64 Daily Weekly Monthly 20 Day Moving Average: 38,063 shares Shares Outstanding: 31.04 (millions) Market Capitalization: $19.76 (millions) Beta: 0.64 52 Week High: $1.74 52 Week Low: $0.48 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -0.52% -4.24% 12 Week -14.62% -28.18% Year To Date -15.11% -20.50%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 10240 BUBB ROAD - CUPERTINO,CA 95014 USA ph: 408-777-1417 fax: 408-777-3577 svonderweid@lifesciadvisors.com http://www.durect.com

• General Corporate Information    Officers James E. Brown - President; Chief Executive Officer and Director Gail J. Maderis - Chairman of the Board and Director Timothy M. Papp - Chief Financial Officer Mohammad Azab - Director Gail M. Farfel - Director Peer Information DURECT Corporation (GSAC) DURECT Corporation (CASI) DURECT Corporation (ALCD.) DURECT Corporation (OMNN) DURECT Corporation (CGPI.) DURECT Corporation (CATX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-DRUGS Sector: Medical CUSIP: 266605500 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/25 Next Expected EPS Date: 08/12/25 Share - Related Items Shares Outstanding: 31.04 Most Recent Split Date: 12.00 (0.10:1) Beta: 0.64 Market Capitalization: $19.76 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.18 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-0.66 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 1.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/12/25

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 3.69 Price/Cash Flow: - Price / Sales: 4.06 EPS Growth vs. Year Ago Period: 48.00% vs. Previous Quarter: -116.67% Sales Growth vs. Year Ago Period: -82.43% vs. Previous Quarter: -29.14% ROE 06/30/25 - - 03/31/25 - -267.36 12/31/24 - -292.84 ROA 06/30/25 - - 03/31/25 - -64.00 12/31/24 - -63.93 Current Ratio 06/30/25 - - 03/31/25 - 1.23 12/31/24 - 1.71 Quick Ratio 06/30/25 - - 03/31/25 - 1.22 12/31/24 - 1.70 Operating Margin 06/30/25 - - 03/31/25 - -284.48 12/31/24 - -271.87 Net Margin 06/30/25 - - 03/31/25 - -91.54 12/31/24 - -123.41 Pre-Tax Margin 06/30/25 - - 03/31/25 - -305.34 12/31/24 - -906.65 Book Value 06/30/25 - - 03/31/25 - 0.17 12/31/24 - 0.29 Inventory Turnover 06/30/25 - - 03/31/25 - 0.06 12/31/24 - 0.04 Debt-to-Equity 06/30/25 - - 03/31/25 - 0.00 12/31/24 - 0.00 Debt-to-Capital 06/30/25 - - 03/31/25 - 0.00 12/31/24 - 0.00

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