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Zacks Company Profile for Aeglea BioTherapeutics, Inc. (AGLE : NSDQ)

• Company Description    Aeglea BioTherapeutics, Inc. is a biotechnology company which is engaged in developing enzyme-based therapeutics in the field of amino acid metabolism to treat inborn errors of metabolism and cancer. Its portfolio of products consists of AEB1102, AEB3103, AEB2109 and AEB4104 which are in different clinical trial phase. Aeglea BioTherapeutics, Inc. is based in Austin, Texas. Number of Employees: 101

• Price / Volume Information    Yesterday's Closing Price: $1.50 Daily Weekly Monthly 20 Day Moving Average: 460,191 shares Shares Outstanding: 50.42 (millions) Market Capitalization: $75.63 (millions) Beta: 1.60 52 Week High: $8.50 52 Week Low: $1.29 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -13.30% -5.06% 12 Week -47.74% -41.26% Year To Date -68.42% -61.42%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 805 LAS CIMAS PARKWAY SUITE 100 - AUSTIN,TX 78746 USA ph: 512-942-2935 fax: 512-872-5121 investors@aeglea.com http://www.aegleabio.com

• General Corporate Information    Officers Anthony G. Quinn - President;ChiefExecutiveOfficer Jonathan Alspaugh - Chief Financial Officer Steven Weber - Vice President and Corporate Controller Russell J. Cox - Director Sandesh Mahatme - Director Peer Information - (-) - (-) - (-) - (-) - (-) - (-) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 00773J103 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/22 Next Expected EPS Date: 08/04/22 Share - Related Items Shares Outstanding: 50.42 Most Recent Split Date: (:1) Beta: 1.60 Market Capitalization: $75.63 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.27 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-1.16 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 4.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/04/22

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 1.23 Price/Cash Flow: - Price / Sales: 3.76 EPS Growth vs. Year Ago Period: -32.14% vs. Previous Quarter: -19.35% Sales Growth vs. Year Ago Period: -% vs. Previous Quarter: -62.62% ROE 03/31/22 - -78.56 12/31/21 - -61.38 09/30/21 - -56.17 ROA 03/31/22 - -61.40 12/31/21 - -47.89 09/30/21 - -45.28 Current Ratio 03/31/22 - 4.45 12/31/21 - 4.91 09/30/21 - 5.75 Quick Ratio 03/31/22 - 4.45 12/31/21 - 4.91 09/30/21 - 5.75 Operating Margin 03/31/22 - -358.29 12/31/21 - - 09/30/21 - - Net Margin 03/31/22 - -358.29 12/31/21 - - 09/30/21 - - Pre-Tax Margin 03/31/22 - -357.58 12/31/21 - -350.39 09/30/21 - -450.16 Book Value 03/31/22 - 1.22 12/31/21 - 1.70 09/30/21 - 2.07 Inventory Turnover 03/31/22 - - 12/31/21 - - 09/30/21 - - Debt-to-Equity 03/31/22 - 0.00 12/31/21 - 0.00 09/30/21 - 0.00 Debt-to-Capital 03/31/22 - 0.00 12/31/21 - 0.00 09/30/21 - 0.00

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