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Zacks Company Profile for Aprea Therapeutics, Inc. (APRE : NSDQ)

• Company Description    Aprea Therapeutics Inc. is a biopharmaceutical company. It is focused on developing and commercializing novel cancer therapeutics which reactivate the mutant tumor suppressor protein, p53. The Company's lead drug candidate, APR-246, a first-in-class small molecule p53 reactivator, is in clinical development for myelodysplastic syndromes, acute myeloid leukemia as well as additional hematologic and solid tumor malignancies. Aprea Therapeutics Inc. is based in Boston, Massachusetts. Number of Employees: 8

• Price / Volume Information    Yesterday's Closing Price: $1.57 Daily Weekly Monthly 20 Day Moving Average: 59,791 shares Shares Outstanding: 5.83 (millions) Market Capitalization: $9.15 (millions) Beta: 1.30 52 Week High: $5.01 52 Week Low: $1.37 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 4.67% 4.16% 12 Week -18.65% -22.32% Year To Date -52.28% -58.47%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 3805 Old Easton Road - DOYLESTOWN,PA 18902 USA ph: 215-948-4119 fax: - mmoyer@lifesciadvisors.com http://www.aprea.com

• General Corporate Information    Officers Oren Gilad - Chief Executive Officer and President John P. Hamill - Chief Financial Officer Jean-Pierre Bizzari - Director Marc Duey - Director Michael Grissinger - Director Peer Information Aprea Therapeutics, Inc. (CORR.) Aprea Therapeutics, Inc. (RSPI) Aprea Therapeutics, Inc. (CGXP) Aprea Therapeutics, Inc. (BGEN) Aprea Therapeutics, Inc. (GTBP) Aprea Therapeutics, Inc. (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 03836J201 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 06/01/25 Next Expected EPS Date: 11/06/25 Share - Related Items Shares Outstanding: 5.83 Most Recent Split Date: 2.00 (0.05:1) Beta: 1.30 Market Capitalization: $9.15 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.11 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-0.71 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 1.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 11/06/25

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.65 Price/Cash Flow: - Price / Sales: 10.86 EPS Growth vs. Year Ago Period: 8.62% vs. Previous Quarter: 19.70% Sales Growth vs. Year Ago Period: -79.00% vs. Previous Quarter: -27.61% ROE 09/30/25 - - 06/30/25 - -78.90 03/31/25 - -68.39 ROA 09/30/25 - - 06/30/25 - -62.67 03/31/25 - -55.74 Current Ratio 09/30/25 - - 06/30/25 - 5.34 03/31/25 - 5.90 Quick Ratio 09/30/25 - - 06/30/25 - 5.34 03/31/25 - 5.90 Operating Margin 09/30/25 - - 06/30/25 - -1,645.01 03/31/25 - -1,095.02 Net Margin 09/30/25 - - 06/30/25 - -1,645.01 03/31/25 - -1,095.02 Pre-Tax Margin 09/30/25 - - 06/30/25 - -1,645.01 03/31/25 - -1,095.02 Book Value 09/30/25 - - 06/30/25 - 2.43 03/31/25 - 2.81 Inventory Turnover 09/30/25 - - 06/30/25 - - 03/31/25 - - Debt-to-Equity 09/30/25 - - 06/30/25 - 0.00 03/31/25 - 0.00 Debt-to-Capital 09/30/25 - - 06/30/25 - 0.00 03/31/25 - 0.00

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