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Zacks Company Profile for Bicycle Therapeutics PLC Sponsored ADR (BCYC : NSDQ)

• Company Description    Bicycle Therapeutics plc is a clinical-stage biopharmaceutical company. It is focused on developing medicines, referred to as Bicycles(R) for diseases which are underserved by existing therapeutics. Bicycle Therapeutics plc is based in Cambridge, United Kingdom. Number of Employees: 119

• Price / Volume Information    Yesterday's Closing Price: $17.10 Daily Weekly Monthly 20 Day Moving Average: 550,193 shares Shares Outstanding: 29.65 (millions) Market Capitalization: $506.95 (millions) Beta: 0.55 52 Week High: $62.08 52 Week Low: $16.08 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -30.40% -23.74% 12 Week -63.03% -59.89% Year To Date -71.91% -66.59%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL B900 BABRAHAM RESEARCH CAMPUS - CAMBRIDGE,X0 CB22 3AT GBR ph: 44-12-2326-1503 fax: - None http://www.bicycletherapeutics.com

• General Corporate Information    Officers Kevin Lee - Chief Executive Officer and Director Pierre Legault - Chairman of the Board and Director Lee Kalowski - Chief Financial Officer and President Janice Bourque - Director Jose-Carlos Gutierrez-Ramos - Director Peer Information Bicycle Therapeutics PLC Sponsored ADR (CORR.) Bicycle Therapeutics PLC Sponsored ADR (RSPI) Bicycle Therapeutics PLC Sponsored ADR (CGXP) Bicycle Therapeutics PLC Sponsored ADR (BGEN) Bicycle Therapeutics PLC Sponsored ADR (GTBP) Bicycle Therapeutics PLC Sponsored ADR (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 088786108 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/22 Next Expected EPS Date: 08/04/22 Share - Related Items Shares Outstanding: 29.65 Most Recent Split Date: (:1) Beta: 0.55 Market Capitalization: $506.95 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.82 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-3.51 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 9.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/04/22

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 1.53 Price/Cash Flow: - Price / Sales: 36.87 EPS Growth vs. Year Ago Period: -27.40% vs. Previous Quarter: -47.62% Sales Growth vs. Year Ago Period: 113.50% vs. Previous Quarter: 2.36% ROE 03/31/22 - -31.61 12/31/21 - -33.36 09/30/21 - -48.12 ROA 03/31/22 - -21.62 12/31/21 - -22.07 09/30/21 - -29.68 Current Ratio 03/31/22 - 12.14 12/31/21 - 12.65 09/30/21 - 9.04 Quick Ratio 03/31/22 - 12.14 12/31/21 - 12.65 09/30/21 - 9.04 Operating Margin 03/31/22 - -568.71 12/31/21 - -571.25 09/30/21 - -562.38 Net Margin 03/31/22 - -568.71 12/31/21 - -571.25 09/30/21 - -562.38 Pre-Tax Margin 03/31/22 - -581.38 12/31/21 - -585.47 09/30/21 - -570.62 Book Value 03/31/22 - 11.14 12/31/21 - 11.78 09/30/21 - 6.13 Inventory Turnover 03/31/22 - - 12/31/21 - - 09/30/21 - - Debt-to-Equity 03/31/22 - 0.09 12/31/21 - 0.09 09/30/21 - 0.17 Debt-to-Capital 03/31/22 - 8.33 12/31/21 - 7.94 09/30/21 - 14.83

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