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Zacks Company Profile for Cyclerion Therapeutics, Inc. (CYCN : NSDQ)

• Company Description    Cyclerion Therapeutics Inc. is a clinical-stage biopharmaceutical company harnessing the power of sGC pharmacology to discover, develop and commercialize breakthrough treatments for serious and orphan diseases. The company's product pipeline consists of Olinciguat, Praliciguat and IW-6463 which are in clinical stage. Cyclerion Therapeutics Inc. is based in Cambridge, United States. Number of Employees: 1

• Price / Volume Information    Yesterday's Closing Price: $1.35 Daily Weekly Monthly 20 Day Moving Average: 41,951 shares Shares Outstanding: 3.93 (millions) Market Capitalization: $5.30 (millions) Beta: 0.95 52 Week High: $6.25 52 Week Low: $1.20 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -14.56% -15.55% 12 Week -46.00% -47.67% Year To Date -58.08% -64.42%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 245 FIRST STREET 18TH FLOOR - CAMBRIDGE,MA 02142 USA ph: 857-327-8778 fax: - ir@cyclerion.com http://www.cyclerion.com

• General Corporate Information    Officers Regina Graul - Chief Executive Officer; President and Director Rhonda Chicko - Chief Financial Officer Errol De Souza - Director Peter Hecht - Director Michael Higgins - Director Peer Information - (-) - (-) - (-) - (-) - (-) - (-) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 23255M204 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 03/03/26 Share - Related Items Shares Outstanding: 3.93 Most Recent Split Date: 5.00 (0.05:1) Beta: 0.95 Market Capitalization: $5.30 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $ Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $ Payout Ratio: Number of Estimates in the Fiscal Year Consensus: Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 03/03/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.47 Price/Cash Flow: - Price / Sales: 1.86 EPS Growth vs. Year Ago Period: -3.45% vs. Previous Quarter: -172.73% Sales Growth vs. Year Ago Period: 351.03% vs. Previous Quarter: 840.86% ROE 09/30/25 - -24.61 06/30/25 - -22.63 03/31/25 - -34.02 ROA 09/30/25 - -22.43 06/30/25 - -20.65 03/31/25 - -30.68 Current Ratio 09/30/25 - 5.78 06/30/25 - 5.03 03/31/25 - 4.21 Quick Ratio 09/30/25 - 5.78 06/30/25 - 5.03 03/31/25 - 4.21 Operating Margin 09/30/25 - -77.02 06/30/25 - -89.51 03/31/25 - - Net Margin 09/30/25 - -77.02 06/30/25 - -89.51 03/31/25 - - Pre-Tax Margin 09/30/25 - -77.02 06/30/25 - -89.51 03/31/25 - -141.47 Book Value 09/30/25 - 2.86 06/30/25 - 2.67 03/31/25 - 2.74 Inventory Turnover 09/30/25 - - 06/30/25 - - 03/31/25 - - Debt-to-Equity 09/30/25 - 0.00 06/30/25 - 0.00 03/31/25 - 0.00 Debt-to-Capital 09/30/25 - 0.00 06/30/25 - 0.00 03/31/25 - 0.00

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