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Zacks Company Profile for Denali Therapeutics Inc. (DNLI : NSDQ)

• Company Description    Denali Therapeutics Inc. is a biotechnology company. It focused on the discovery and development of therapies for patients with neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and others. Denali Therapeutics Inc. is based in SOUTH SAN FRANCISCO, United States. Number of Employees: 380

• Price / Volume Information    Yesterday's Closing Price: $23.27 Daily Weekly Monthly 20 Day Moving Average: 638,894 shares Shares Outstanding: 122.95 (millions) Market Capitalization: $2,861.01 (millions) Beta: 1.90 52 Week High: $79.70 52 Week Low: $20.24 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -18.44% -10.63% 12 Week -28.58% -22.50% Year To Date -47.83% -37.96%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 161 OYSTER POINT BLVD. - SOUTH SAN FRANCISCO,CA 94080 USA ph: 650-866-8548 fax: - hansen@dnli.com http://www.denalitherapeutics.com

• General Corporate Information    Officers Ryan J. Watts - President; Chief Executive Officer and Director Vicki Sato - Chairperson Steve E. Krognes - Chief Financial Officer and Treasurer Marc Tessier-Lavigne - Director Douglas Cole - Director Peer Information Denali Therapeutics Inc. (CORR.) Denali Therapeutics Inc. (RSPI) Denali Therapeutics Inc. (CGXP) Denali Therapeutics Inc. (BGEN) Denali Therapeutics Inc. (GTBP) Denali Therapeutics Inc. (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 24823R105 SIC: 2836 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/22 Next Expected EPS Date: 08/03/22 Share - Related Items Shares Outstanding: 122.95 Most Recent Split Date: (:1) Beta: 1.90 Market Capitalization: $2,861.01 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.56 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-2.68 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 9.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/03/22

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 2.95 Price/Cash Flow: - Price / Sales: 34.52 EPS Growth vs. Year Ago Period: 8.62% vs. Previous Quarter: 14.52% Sales Growth vs. Year Ago Period: 431.88% vs. Previous Quarter: 236.75% ROE 03/31/22 - -28.13 12/31/21 - -27.99 09/30/21 - 2.72 ROA 03/31/22 - -19.65 12/31/21 - -19.66 09/30/21 - 1.93 Current Ratio 03/31/22 - - 12/31/21 - 2.37 09/30/21 - 19.46 Quick Ratio 03/31/22 - - 12/31/21 - 2.37 09/30/21 - 19.46 Operating Margin 03/31/22 - -344.79 12/31/21 - -597.15 09/30/21 - 8.38 Net Margin 03/31/22 - -344.79 12/31/21 - -597.15 09/30/21 - 8.38 Pre-Tax Margin 03/31/22 - - 12/31/21 - -598.34 09/30/21 - 8.61 Book Value 03/31/22 - - 12/31/21 - 7.88 09/30/21 - 8.29 Inventory Turnover 03/31/22 - - 12/31/21 - - 09/30/21 - - Debt-to-Equity 03/31/22 - - 12/31/21 - 0.00 09/30/21 - 0.00 Debt-to-Capital 03/31/22 - - 12/31/21 - 0.00 09/30/21 - 0.00

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