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Zacks Company Profile for Lyra Therapeutics, Inc. (LYRA : NSDQ)

• Company Description    Lyra Therapeutics Inc. is a clinical-stage therapeutics company. It is focused on the development and commercialization of novel integrated drug and delivery solutions for patients with ear, nose and throat diseases. The company's proprietary technology platform, XTreo(TM), is designed to precisely and consistently deliver medicines directly to the affected tissue. Its initial product candidates consist LYR-210 and LYR-220 which are in clinical stage. Lyra Therapeutics Inc. is based in Watertown, Mass. Number of Employees: 30

• Price / Volume Information    Yesterday's Closing Price: $3.93 Daily Weekly Monthly 20 Day Moving Average: 92,491 shares Shares Outstanding: 1.77 (millions) Market Capitalization: $6.98 (millions) Beta: -0.02 52 Week High: $37.50 52 Week Low: $2.84 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 5.08% 2.86% 12 Week -38.78% -39.89% Year To Date -61.92% -67.14%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 480 ARSENAL STREET - WATERTOWN,MA 02472 USA ph: 617-393-4600 fax: - ir@lyratx.com https://lyratherapeutics.com

• General Corporate Information    Officers Maria Palasis - President and Chief Executive Officer Harlan W. Waksal - Executive Chair and Chairperson of the Board Jason Cavalier - Chief Financial Officer and Treasurer W. Bradford Smith - Director C. Ann Merrifield - Director Peer Information Lyra Therapeutics, Inc. (GSAC) Lyra Therapeutics, Inc. (CASI) Lyra Therapeutics, Inc. (ALCD.) Lyra Therapeutics, Inc. (OMNN) Lyra Therapeutics, Inc. (CGPI.) Lyra Therapeutics, Inc. (CATX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-DRUGS Sector: Medical CUSIP: 55234L204 SIC: 3841 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 03/12/26 Share - Related Items Shares Outstanding: 1.77 Most Recent Split Date: 5.00 (0.02:1) Beta: -0.02 Market Capitalization: $6.98 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-1.24 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-11.26 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 1.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 03/12/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: - Price/Cash Flow: - Price / Sales: 11.63 EPS Growth vs. Year Ago Period: 62.44% vs. Previous Quarter: 38.66% Sales Growth vs. Year Ago Period: -87.18% vs. Previous Quarter: -86.34% ROE 09/30/25 - -1,010.91 06/30/25 - -404.56 03/31/25 - -295.52 ROA 09/30/25 - -58.92 06/30/25 - -60.06 03/31/25 - -66.95 Current Ratio 09/30/25 - 2.43 06/30/25 - 2.78 03/31/25 - 2.96 Quick Ratio 09/30/25 - 2.43 06/30/25 - 2.78 03/31/25 - 2.96 Operating Margin 09/30/25 - -5,374.67 06/30/25 - -4,952.86 03/31/25 - -4,181.01 Net Margin 09/30/25 - -5,491.17 06/30/25 - -5,043.64 03/31/25 - -6,711.39 Pre-Tax Margin 09/30/25 - -5,488.67 06/30/25 - -5,041.17 03/31/25 - -6,708.94 Book Value 09/30/25 - -2.63 06/30/25 - 1.01 03/31/25 - 2.94 Inventory Turnover 09/30/25 - - 06/30/25 - - 03/31/25 - - Debt-to-Equity 09/30/25 - - 06/30/25 - 0.00 03/31/25 - 0.00 Debt-to-Capital 09/30/25 - - 06/30/25 - 0.00 03/31/25 - 0.00

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