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Zacks Company Profile for Metacrine, Inc. (MTCR : NSDQ)

• Company Description    Metacrine Inc. is a clinical-stage biopharmaceutical company. It is focused on discovering and developing therapies for patients with liver and gastrointestinal diseases. The company's program includes MET409 and MET642 which are in clinical trial. Metacrine Inc. is based in San Diego, United States. Number of Employees: 32

• Price / Volume Information    Yesterday's Closing Price: $0.43 Daily Weekly Monthly 20 Day Moving Average: 805,259 shares Shares Outstanding: 42.47 (millions) Market Capitalization: $18.13 (millions) Beta: -1.03 52 Week High: $4.84 52 Week Low: $0.35 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -9.63% -1.05% 12 Week -9.15% 2.11% Year To Date -36.67% -22.63%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 4225 EXECUTIVE SQUARE SUITE 600 - SAN DIEGO,CA 92037 USA ph: 858-369-7800 fax: - investors@metacrine.com http://www.metacrine.com

• General Corporate Information    Officers Preston Klassen - President and Chief Executive Officer Richard Heyman - Chairman of the Board Patricia Millican - Chief Financial Officer Jeffrey Jonker - Director Julia Owens - Director Peer Information - (-) - (-) - (-) - (-) - (-) - (-) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 59101E103 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/22 Next Expected EPS Date: 08/11/22 Share - Related Items Shares Outstanding: 42.47 Most Recent Split Date: (:1) Beta: -1.03 Market Capitalization: $18.13 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.40 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-1.15 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 2.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/11/22

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.39 Price/Cash Flow: - Price / Sales: - EPS Growth vs. Year Ago Period: 43.86% vs. Previous Quarter: 27.27% Sales Growth vs. Year Ago Period: -% vs. Previous Quarter: -% ROE 03/31/22 - -113.60 12/31/21 - -101.81 09/30/21 - -86.13 ROA 03/31/22 - -82.30 12/31/21 - -77.38 09/30/21 - -68.82 Current Ratio 03/31/22 - 12.19 12/31/21 - 10.15 09/30/21 - 6.33 Quick Ratio 03/31/22 - 12.19 12/31/21 - 10.15 09/30/21 - 6.33 Operating Margin 03/31/22 - - 12/31/21 - - 09/30/21 - - Net Margin 03/31/22 - - 12/31/21 - - 09/30/21 - - Pre-Tax Margin 03/31/22 - - 12/31/21 - - 09/30/21 - - Book Value 03/31/22 - 1.10 12/31/21 - 1.36 09/30/21 - 1.78 Inventory Turnover 03/31/22 - - 12/31/21 - - 09/30/21 - - Debt-to-Equity 03/31/22 - 0.29 12/31/21 - 0.23 09/30/21 - 0.19 Debt-to-Capital 03/31/22 - 22.42 12/31/21 - 18.83 09/30/21 - 16.19

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