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Zacks Company Profile for Orchestra BioMed Holdings, Inc. (OBIO : NSDQ)

• Company Description    Orchestra BioMed Inc. is a biomedical company accelerating high-impact technologies to patients. The company's flagship product candidates include BackBeat Cardiac Neuromodulation Therapy(TM)for the treatment of hypertension and Virtue(R) Sirolimus AngioInfusion(TM) Balloon for the treatment of atherosclerotic artery disease. Orchestra BioMed Inc., formerly known as Health Sciences Acquisitions Corporation 2, is based in NEW HOPE, Pa. Number of Employees: 70

• Price / Volume Information    Yesterday's Closing Price: $4.51 Daily Weekly Monthly 20 Day Moving Average: 292,618 shares Shares Outstanding: 56.47 (millions) Market Capitalization: $254.66 (millions) Beta: 0.62 52 Week High: $6.30 52 Week Low: $2.20 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 7.89% 6.47% 12 Week 79.68% 74.54% Year To Date 12.75% -2.63%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 150 UNION SQUARE DRIVE - NEW HOPE,PA 18938 USA ph: 215-862-5797 fax: - snewcomb@orchestrabiomed.com https://orchestrabiomed.com

• General Corporate Information    Officers David P. Hochman - Chief Executive Officer; Chairperson and Director Darren R. Sherman - President; Chief Operating Officer and Director Andrew L. Taylor - Chief Financial Officer Joshua Aiello - Corporate Controller Jason Aryeh - Director Peer Information Orchestra BioMed Holdings, Inc. (CORR.) Orchestra BioMed Holdings, Inc. (RSPI) Orchestra BioMed Holdings, Inc. (CGXP) Orchestra BioMed Holdings, Inc. (BGEN) Orchestra BioMed Holdings, Inc. (GTBP) Orchestra BioMed Holdings, Inc. (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 68572M106 SIC: 3841 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 03/30/26 Share - Related Items Shares Outstanding: 56.47 Most Recent Split Date: (:1) Beta: 0.62 Market Capitalization: $254.66 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.39 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-1.75 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 4.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 03/30/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 5.82 Price/Cash Flow: - Price / Sales: 90.37 EPS Growth vs. Year Ago Period: 2.44% vs. Previous Quarter: 20.00% Sales Growth vs. Year Ago Period: -12.77% vs. Previous Quarter: 2.99% ROE 09/30/25 - -320.09 06/30/25 - -289.42 03/31/25 - -189.26 ROA 09/30/25 - -106.20 06/30/25 - -110.04 03/31/25 - -93.76 Current Ratio 09/30/25 - 4.73 06/30/25 - 2.10 03/31/25 - 3.35 Quick Ratio 09/30/25 - 4.72 06/30/25 - 2.09 03/31/25 - 3.34 Operating Margin 09/30/25 - -2,665.05 06/30/25 - -2,367.49 03/31/25 - -2,297.85 Net Margin 09/30/25 - -2,665.05 06/30/25 - -2,367.49 03/31/25 - -2,297.85 Pre-Tax Margin 09/30/25 - -2,665.05 06/30/25 - -2,367.49 03/31/25 - -2,297.85 Book Value 09/30/25 - 0.77 06/30/25 - 0.01 03/31/25 - 0.44 Inventory Turnover 09/30/25 - 0.92 06/30/25 - 1.19 03/31/25 - 1.40 Debt-to-Equity 09/30/25 - 0.32 06/30/25 - 48.76 03/31/25 - 0.85 Debt-to-Capital 09/30/25 - 24.51 06/30/25 - 97.99 03/31/25 - 45.96

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