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Zacks Company Profile for Prothena Corporation plc (PRTA : NSDQ)

• Company Description    Prothena Corp. plc, being a clinical-stage neuroscience company, focused on the development of novel therapeutic therapies for life-threatening diseases. Its wholly owned programs include birtamimab for the potential treatment of AL amyloidosis, PRX004 for the potential treatment of ATTR amyloidosis and a portfolio of programs for the potential treatment of Alzheimer's disease including PRX012 that targets A?.?Prothena is also developing candidates in collaboration with bigwigs like Roche and Bristol-Myers Squibb. These programs include prasinezumab, in collaboration with Roche for the potential treatment of Parkinson's disease and other related synucleinopathies, and programs that target tau, TDP-43 and an undisclosed target in collaboration with Bristol-Myers Squibb for the potential treatment of Alzheimer's disease, amyotrophic lateralsclerosis, etc. It sold PRX004 and the broader ATTR amyloidosis program to Novo Nordisk. It derives revenues from license, development & commercialization agreements. Number of Employees: 163

• Price / Volume Information    Yesterday's Closing Price: $6.22 Daily Weekly Monthly 20 Day Moving Average: 1,431,144 shares Shares Outstanding: 53.83 (millions) Market Capitalization: $334.80 (millions) Beta: 0.01 52 Week High: $25.42 52 Week Low: $4.32 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 9.12% 4.56% 12 Week -34.80% -44.78% Year To Date -55.09% -57.69%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 77 SIR JOHN ROGERSON`S QUAY BLOCK C GRAND CANAL DOCKLANDS - DUBLIN,L2 D02 VK60 IRL ph: 011-353-1236-2500 fax: 353-1902-3510 mark.johnson@prothena.com http://www.prothena.com

• General Corporate Information    Officers Gene G. Kinney - Chief Executive Officer and President Daniel G. Welch - Chair of the Board Tran B. Nguyen - Chief Financial Officer Paula K. Cobb - Director Richard T. Collier - Director Peer Information Prothena Corporation plc (CORR.) Prothena Corporation plc (RSPI) Prothena Corporation plc (CGXP) Prothena Corporation plc (BGEN) Prothena Corporation plc (GTBP) Prothena Corporation plc (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: G72800108 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/25 Next Expected EPS Date: 08/14/25 Share - Related Items Shares Outstanding: 53.83 Most Recent Split Date: (:1) Beta: 0.01 Market Capitalization: $334.80 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.96 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-3.94 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 7.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/14/25

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.76 Price/Cash Flow: - Price / Sales: 2.43 EPS Growth vs. Year Ago Period: 16.42% vs. Previous Quarter: -3.70% Sales Growth vs. Year Ago Period: 5,556.00% vs. Previous Quarter: 33.21% ROE 06/30/25 - - 03/31/25 - -21.61 12/31/24 - -23.24 ROA 06/30/25 - - 03/31/25 - -19.32 12/31/24 - -20.29 Current Ratio 06/30/25 - - 03/31/25 - 9.00 12/31/24 - 10.01 Quick Ratio 06/30/25 - - 03/31/25 - 9.00 12/31/24 - 10.01 Operating Margin 06/30/25 - - 03/31/25 - -79.94 12/31/24 - -90.50 Net Margin 06/30/25 - - 03/31/25 - -79.94 12/31/24 - -90.50 Pre-Tax Margin 06/30/25 - - 03/31/25 - -84.00 12/31/24 - -95.39 Book Value 06/30/25 - - 03/31/25 - 8.13 12/31/24 - 9.05 Inventory Turnover 06/30/25 - - 03/31/25 - - 12/31/24 - - Debt-to-Equity 06/30/25 - - 03/31/25 - 0.00 12/31/24 - 0.00 Debt-to-Capital 06/30/25 - - 03/31/25 - 0.00 12/31/24 - 0.00

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