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Zacks Company Profile for Bicycle Therapeutics PLC Sponsored ADR (BCYC : NSDQ)

• Company Description    Bicycle Therapeutics plc is a clinical-stage biopharmaceutical company. It is focused on developing medicines, referred to as Bicycles(R) for diseases which are underserved by existing therapeutics. Bicycle Therapeutics plc is based in Cambridge, United Kingdom. Number of Employees: 305

• Price / Volume Information    Yesterday's Closing Price: $6.44 Daily Weekly Monthly 20 Day Moving Average: 342,428 shares Shares Outstanding: 69.31 (millions) Market Capitalization: $446.33 (millions) Beta: 1.48 52 Week High: $25.39 52 Week Low: $6.10 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -22.60% -24.62% 12 Week -13.44% -17.03% Year To Date -54.00% -59.79%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL BLOCKS A & B PORTWAY BUILDING GRANTA PARK GREAT ABINGTON - CAMBRIDGE,X0 CB21 6GS GBR ph: 44-12-2326-1503 fax: - ir@bicycletx.com http://www.bicycletherapeutics.com

• General Corporate Information    Officers Kevin Lee - Chief Executive Officer and Director Pierre Legault - Chairman of the Board and Director Alethia Young - Chief Financial Officer Travis Thompson - Chief Accounting Officer Felix J. Baker - Director Peer Information Bicycle Therapeutics PLC Sponsored ADR (CORR.) Bicycle Therapeutics PLC Sponsored ADR (RSPI) Bicycle Therapeutics PLC Sponsored ADR (CGXP) Bicycle Therapeutics PLC Sponsored ADR (BGEN) Bicycle Therapeutics PLC Sponsored ADR (GTBP) Bicycle Therapeutics PLC Sponsored ADR (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 088786108 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 02/24/26 Share - Related Items Shares Outstanding: 69.31 Most Recent Split Date: (:1) Beta: 1.48 Market Capitalization: $446.33 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-1.00 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-3.95 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 6.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 02/24/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.72 Price/Cash Flow: - Price / Sales: 15.75 EPS Growth vs. Year Ago Period: -14.86% vs. Previous Quarter: 25.44% Sales Growth vs. Year Ago Period: 338.49% vs. Previous Quarter: 301.85% ROE 09/30/25 - -36.05 06/30/25 - -32.43 03/31/25 - -25.54 ROA 09/30/25 - -29.58 06/30/25 - -26.80 03/31/25 - -21.23 Current Ratio 09/30/25 - 10.66 06/30/25 - 10.39 03/31/25 - 14.86 Quick Ratio 09/30/25 - 10.66 06/30/25 - 10.39 03/31/25 - 14.86 Operating Margin 09/30/25 - -896.98 06/30/25 - -1,275.34 03/31/25 - -803.82 Net Margin 09/30/25 - -884.51 06/30/25 - -1,257.00 03/31/25 - -790.07 Pre-Tax Margin 09/30/25 - -892.25 06/30/25 - -1,287.33 03/31/25 - -811.46 Book Value 09/30/25 - 8.92 06/30/25 - 9.66 03/31/25 - 10.69 Inventory Turnover 09/30/25 - - 06/30/25 - - 03/31/25 - - Debt-to-Equity 09/30/25 - 0.00 06/30/25 - 0.00 03/31/25 - 0.00 Debt-to-Capital 09/30/25 - 0.00 06/30/25 - 0.00 03/31/25 - 0.00

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