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Zacks Company Profile for Karyopharm Therapeutics Inc. (KPTI : NSDQ)

• Company Description    Karyopharm Therapeutics, Inc. is a clinical-stage pharmaceutical company focused on the discovery and development of drugs for the treatment of cancer and other major diseases. It serves the healthcare industry throughout the United States. Karyopharm Therapeutics, Inc. is based in United States. Number of Employees: 279

• Price / Volume Information    Yesterday's Closing Price: $5.16 Daily Weekly Monthly 20 Day Moving Average: 144,235 shares Shares Outstanding: 17.05 (millions) Market Capitalization: $87.98 (millions) Beta: 0.35 52 Week High: $14.24 52 Week Low: $3.51 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -6.18% -8.64% 12 Week -12.84% -16.45% Year To Date -49.11% -55.52%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 85 WELLS AVENUE SECOND FLOOR - NEWTON,MA 02459 USA ph: 617-658-0600 fax: - investorrelations@karyopharm.com http://www.karyopharm.com

• General Corporate Information    Officers Richard Paulson - President and Chief Executive Officer Lori Macomber - Executive Vice President; Chief Financial Officer Michael Mano - Senior Vice President; General Counsel and Secreta Kristin Abate - Vice President; Chief Accounting Officer and Assis Garen G. Bohlin - Director Peer Information Karyopharm Therapeutics Inc. (GSAC) Karyopharm Therapeutics Inc. (CASI) Karyopharm Therapeutics Inc. (ALCD.) Karyopharm Therapeutics Inc. (OMNN) Karyopharm Therapeutics Inc. (CGPI.) Karyopharm Therapeutics Inc. (CATX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-DRUGS Sector: Medical CUSIP: 48576U205 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 02/18/26 Share - Related Items Shares Outstanding: 17.05 Most Recent Split Date: 2.00 (0.07:1) Beta: 0.35 Market Capitalization: $87.98 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-2.26 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-12.43 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 3.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 02/18/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: - Price/Cash Flow: - Price / Sales: 0.62 EPS Growth vs. Year Ago Period: 2.00% vs. Previous Quarter: 11.57% Sales Growth vs. Year Ago Period: 13.57% vs. Previous Quarter: 16.12% ROE 09/30/25 - - 06/30/25 - - 03/31/25 - - ROA 09/30/25 - -101.06 06/30/25 - -84.28 03/31/25 - -35.95 Current Ratio 09/30/25 - 1.03 06/30/25 - 0.99 03/31/25 - 1.33 Quick Ratio 09/30/25 - 0.98 06/30/25 - 0.94 03/31/25 - 1.28 Operating Margin 09/30/25 - -87.43 06/30/25 - -90.02 03/31/25 - -43.99 Net Margin 09/30/25 - -87.43 06/30/25 - -90.02 03/31/25 - -43.99 Pre-Tax Margin 09/30/25 - -87.43 06/30/25 - -90.02 03/31/25 - -43.97 Book Value 09/30/25 - -15.79 06/30/25 - -27.65 03/31/25 - -24.02 Inventory Turnover 09/30/25 - 1.26 06/30/25 - 1.04 03/31/25 - 1.22 Debt-to-Equity 09/30/25 - - 06/30/25 - - 03/31/25 - - Debt-to-Capital 09/30/25 - - 06/30/25 - - 03/31/25 - -

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