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Zacks Company Profile for Karyopharm Therapeutics Inc. (KPTI : NSDQ)

• Company Description    Karyopharm Therapeutics, Inc. is a clinical-stage pharmaceutical company focused on the discovery and development of drugs for the treatment of cancer and other major diseases. It serves the healthcare industry throughout the United States. Karyopharm Therapeutics, Inc. is based in United States. Number of Employees: 228

• Price / Volume Information    Yesterday's Closing Price: $8.16 Daily Weekly Monthly 20 Day Moving Average: 440,444 shares Shares Outstanding: 22.66 (millions) Market Capitalization: $184.93 (millions) Beta: 0.80 52 Week High: $10.99 52 Week Low: $3.65 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -6.74% -11.30% 12 Week -12.73% -19.32% Year To Date 10.87% 0.68%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 85 WELLS AVENUE SECOND FLOOR - NEWTON,MA 02459 USA ph: 617-658-0600 fax: - investorrelations@karyopharm.com http://www.karyopharm.com

• General Corporate Information    Officers Richard Paulson - President and Chief Executive Officer Lori Macomber - Executive Vice President; Chief Financial Officer Michael Mano - Executive Vice President; Chief Legal Officer and Kristin Abate - Vice President; Chief Accounting Officer and Assis Garen G. Bohlin - Director Peer Information Karyopharm Therapeutics Inc. (GSAC) Karyopharm Therapeutics Inc. (CASIF) Karyopharm Therapeutics Inc. (ALCD.) Karyopharm Therapeutics Inc. (OMNN) Karyopharm Therapeutics Inc. (CGPI.) Karyopharm Therapeutics Inc. (CATX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-DRUGS Sector: Medical CUSIP: 48576U205 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/26 Next Expected EPS Date: 08/10/26 Share - Related Items Shares Outstanding: 22.66 Most Recent Split Date: 2.00 (0.07:1) Beta: 0.80 Market Capitalization: $184.93 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-1.33 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-3.52 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 3.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/10/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: - Price/Cash Flow: - Price / Sales: 1.22 EPS Growth vs. Year Ago Period: 55.23% vs. Previous Quarter: 44.39% Sales Growth vs. Year Ago Period: 16.83% vs. Previous Quarter: 2.90% ROE 03/31/26 - - 12/31/25 - - 09/30/25 - - ROA 03/31/26 - -120.29 12/31/25 - -122.29 09/30/25 - -101.06 Current Ratio 03/31/26 - 1.08 12/31/25 - 1.12 09/30/25 - 1.03 Quick Ratio 03/31/26 - 1.05 12/31/25 - 1.08 09/30/25 - 0.98 Operating Margin 03/31/26 - -87.75 12/31/25 - -91.52 09/30/25 - -87.43 Net Margin 03/31/26 - -129.02 12/31/25 - -134.21 09/30/25 - -87.43 Pre-Tax Margin 03/31/26 - -129.01 12/31/25 - -134.18 09/30/25 - -87.43 Book Value 03/31/26 - -11.72 12/31/25 - -16.00 09/30/25 - -15.79 Inventory Turnover 03/31/26 - 1.44 12/31/25 - 1.34 09/30/25 - 1.26 Debt-to-Equity 03/31/26 - - 12/31/25 - - 09/30/25 - - Debt-to-Capital 03/31/26 - - 12/31/25 - - 09/30/25 - -

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