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Zacks Company Profile for NuCana PLC Sponsored ADR (NCNA : NSDQ)

• Company Description    NuCana PLC is a clinical-stage biopharmaceutical company. It focused on improving treatment outcomes for cancer patients by applying its phosphoramidate chemistry technology. The company's pipeline of products includes Acelarin, NUC-3373 and NUC-7738 which are in clinical stage. NuCana PLC is based in EDINBURGH, United Kingdom. Number of Employees: 12

• Price / Volume Information    Yesterday's Closing Price: $2.02 Daily Weekly Monthly 20 Day Moving Average: 38,297 shares Shares Outstanding: 4.16 (millions) Market Capitalization: $8.41 (millions) Beta: 2.17 52 Week High: $40.00 52 Week Low: $1.33 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -6.05% -10.64% 12 Week -7.76% -14.73% Year To Date -43.89% -48.16%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 3 Lochside Way - Edinburgh,X0 EH12 9DT GBR ph: 44-0-13-1357-1111 fax: - chris.brinzey@westwicke.com http://www.nucana.com

• General Corporate Information    Officers Hugh S. Griffith - Chief Executive Officer and Director Andrew Kay - Non-Executive Director and Chairman Ian Webster - Interim Chief Financial Officer Martin Mellish - Director Cyrille Leperlier - Director Peer Information - (-) - (-) - (-) - (-) - (-) - (-) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 67022C304 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 03/01/26 Next Expected EPS Date: 08/19/26 Share - Related Items Shares Outstanding: 4.16 Most Recent Split Date: 8.00 (0.01:1) Beta: 2.17 Market Capitalization: $8.41 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $ Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $ Payout Ratio: Number of Estimates in the Fiscal Year Consensus: Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 08/19/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.28 Price/Cash Flow: - Price / Sales: - EPS Growth vs. Year Ago Period: 99.01% vs. Previous Quarter: 14.97% Sales Growth vs. Year Ago Period: -% vs. Previous Quarter: -% ROE 03/31/26 - -153.61 12/31/25 - -189.94 09/30/25 - -253.41 ROA 03/31/26 - -116.03 12/31/25 - -130.93 09/30/25 - -148.06 Current Ratio 03/31/26 - 5.48 12/31/25 - 5.60 09/30/25 - 4.76 Quick Ratio 03/31/26 - - 12/31/25 - 5.60 09/30/25 - 4.76 Operating Margin 03/31/26 - - 12/31/25 - - 09/30/25 - - Net Margin 03/31/26 - - 12/31/25 - - 09/30/25 - - Pre-Tax Margin 03/31/26 - - 12/31/25 - - 09/30/25 - - Book Value 03/31/26 - 7.24 12/31/25 - 7.71 09/30/25 - 1,150.11 Inventory Turnover 03/31/26 - - 12/31/25 - - 09/30/25 - - Debt-to-Equity 03/31/26 - 0.00 12/31/25 - 0.00 09/30/25 - 0.00 Debt-to-Capital 03/31/26 - 0.00 12/31/25 - 0.00 09/30/25 - 0.00

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