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Zacks Company Profile for Septerna, Inc. (SEPN : NSDQ)

• Company Description    Septerna Inc. is a clinical-stage biotechnology company pioneering a new era of GPCR oral small molecule drug discovery powered by its proprietary Native Complex Platform(TM). Septerna Inc. is based in SOUTH SAN FRANCISCO, Calif. Number of Employees: 130

• Price / Volume Information    Yesterday's Closing Price: $40.41 Daily Weekly Monthly 20 Day Moving Average: 410,976 shares Shares Outstanding: 46.68 (millions) Market Capitalization: $1,886.22 (millions) Beta: 2.29 52 Week High: $51.10 52 Week Low: $17.55 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 5.98% 7.10% 12 Week 14.87% 12.06% Year To Date 44.94% 30.98%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 250 EAST GRAND AVENUE - SOUTH SAN FRANCISCO,CA 94080 USA ph: 650-338-3533 fax: - investors@septerna.com https://septerna.com

• General Corporate Information    Officers Jeffrey Finer - Chief Executive Officer and Director Jeffrey Tong - Chairman and Director Gil M. Labrucherie - Chief Financial Officer Abraham Bassan - Director Bernard Coulie - Director Peer Information Septerna, Inc. (CORR.) Septerna, Inc. (RSPI) Septerna, Inc. (CGXP) Septerna, Inc. (BGEN) Septerna, Inc. (GTBP) Septerna, Inc. (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 81734D104 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 06/01/26 Next Expected EPS Date: 11/09/26 Share - Related Items Shares Outstanding: 46.68 Most Recent Split Date: (:1) Beta: 2.29 Market Capitalization: $1,886.22 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.57 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-1.41 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 7.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 11/09/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 4.71 Price/Cash Flow: - Price / Sales: 19.08 EPS Growth vs. Year Ago Period: 48.21% vs. Previous Quarter: -52.63% Sales Growth vs. Year Ago Period: 22,375.63% vs. Previous Quarter: 0.84% ROE 09/30/26 - - 06/30/26 - -9.57 03/31/26 - -12.72 ROA 09/30/26 - - 06/30/26 - -6.28 03/31/26 - -8.87 Current Ratio 09/30/26 - - 06/30/26 - 4.99 03/31/26 - 4.71 Quick Ratio 09/30/26 - - 06/30/26 - 4.99 03/31/26 - 4.71 Operating Margin 09/30/26 - - 06/30/26 - -37.15 03/31/26 - -67.18 Net Margin 09/30/26 - - 06/30/26 - -24.51 03/31/26 - -49.88 Pre-Tax Margin 09/30/26 - - 06/30/26 - -23.17 03/31/26 - -49.40 Book Value 09/30/26 - - 06/30/26 - 8.58 03/31/26 - 8.42 Inventory Turnover 09/30/26 - - 06/30/26 - - 03/31/26 - - Debt-to-Equity 09/30/26 - - 06/30/26 - 0.00 03/31/26 - 0.00 Debt-to-Capital 09/30/26 - - 06/30/26 - 0.00 03/31/26 - 0.00

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