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Zacks Company Profile for Spero Therapeutics, Inc. (SPRO : NSDQ)

• Company Description    Spero Therapeutics Inc. is a multi-asset, clinical-stage biopharmaceutical company. It focused on identifying, developing and commercializing novel treatments for multi-drug resistant bacterial infections. Spero Therapeutics Inc. is based in CAMBRIDGE, United States. Number of Employees: 25

• Price / Volume Information    Yesterday's Closing Price: $1.21 Daily Weekly Monthly 20 Day Moving Average: 441,458 shares Shares Outstanding: 58.24 (millions) Market Capitalization: $70.46 (millions) Beta: 1.49 52 Week High: $3.08 52 Week Low: $1.08 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week -1.63% -1.19% 12 Week -58.42% -59.30% Year To Date -48.07% -53.94%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 675 Massachusetts Avenue 14th Floor - Cambridge,MA 02139 USA ph: 857-242-1600 fax: - ir@sperotherapeutics.com https://sperotherapeutics.com

• General Corporate Information    Officers Esther Rajavelu - President; Chief Executive Officer; Chief Financia Milind Deshpande - Director Scott Jackson - Director John C. Pottage - Director Cynthia Smith - Director Peer Information Spero Therapeutics, Inc. (CORR.) Spero Therapeutics, Inc. (RSPI) Spero Therapeutics, Inc. (CGXP) Spero Therapeutics, Inc. (BGEN) Spero Therapeutics, Inc. (GTBP) Spero Therapeutics, Inc. (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 84833T103 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 06/01/26 Next Expected EPS Date: 11/12/26 Share - Related Items Shares Outstanding: 58.24 Most Recent Split Date: (:1) Beta: 1.49 Market Capitalization: $70.46 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $ Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $ Payout Ratio: 0.00 Number of Estimates in the Fiscal Year Consensus: Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 11/12/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: 11.00 PEG Ratio: - Price Ratios Price/Book: 1.58 Price/Cash Flow: 7.95 Price / Sales: 1.15 EPS Growth vs. Year Ago Period: -433.33% vs. Previous Quarter: -23.08% Sales Growth vs. Year Ago Period: -95.61% vs. Previous Quarter: -99.38% ROE 06/30/26 - 16.17 03/31/26 - 35.58 12/31/25 - 22.53 ROA 06/30/26 - 12.57 03/31/26 - 24.95 12/31/25 - 13.04 Current Ratio 06/30/26 - 6.12 03/31/26 - 10.50 12/31/25 - 7.59 Quick Ratio 06/30/26 - 6.12 03/31/26 - 10.50 12/31/25 - 7.59 Operating Margin 06/30/26 - - 03/31/26 - 24.90 12/31/25 - 12.83 Net Margin 06/30/26 - - 03/31/26 - 24.90 12/31/25 - 12.83 Pre-Tax Margin 06/30/26 - 16.26 03/31/26 - 25.33 12/31/25 - 13.22 Book Value 06/30/26 - 0.76 03/31/26 - 0.91 12/31/25 - 1.05 Inventory Turnover 06/30/26 - - 03/31/26 - - 12/31/25 - - Debt-to-Equity 06/30/26 - 0.00 03/31/26 - 0.00 12/31/25 - 0.00 Debt-to-Capital 06/30/26 - 0.00 03/31/26 - 0.00 12/31/25 - 0.00

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