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Zacks Company Profile for Spero Therapeutics, Inc. (SPRO : NSDQ)

• Company Description    Spero Therapeutics Inc. is a multi-asset, clinical-stage biopharmaceutical company. It focused on identifying, developing and commercializing novel treatments for multi-drug resistant bacterial infections. Spero Therapeutics Inc. is based in CAMBRIDGE, United States. Number of Employees: 32

• Price / Volume Information    Yesterday's Closing Price: $2.33 Daily Weekly Monthly 20 Day Moving Average: 228,608 shares Shares Outstanding: 56.34 (millions) Market Capitalization: $131.27 (millions) Beta: 1.46 52 Week High: $3.22 52 Week Low: $0.51 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 2.19% 2.37% 12 Week -1.27% -2.86% Year To Date 0.00% 0.00%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 675 Massachusetts Avenue 14th Floor - Cambridge,MA 02139 USA ph: 857-242-1600 fax: - ir@sperotherapeutics.com https://sperotherapeutics.com

• General Corporate Information    Officers Esther Rajavelu - Chief Executive Officer; Chief Financial Officer; Milind Deshpande - Director Scott Jackson - Director Cynthia Smith - Director Kathleen Tregoning - Director Peer Information Spero Therapeutics, Inc. (CORR.) Spero Therapeutics, Inc. (RSPI) Spero Therapeutics, Inc. (CGXP) Spero Therapeutics, Inc. (BGEN) Spero Therapeutics, Inc. (GTBP) Spero Therapeutics, Inc. (RGRX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-BIOMED/GENE Sector: Medical CUSIP: 84833T103 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 03/26/26 Share - Related Items Shares Outstanding: 56.34 Most Recent Split Date: (:1) Beta: 1.46 Market Capitalization: $131.27 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $ Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $ Payout Ratio: Number of Estimates in the Fiscal Year Consensus: Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 03/26/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 4.95 Price/Cash Flow: - Price / Sales: 3.24 EPS Growth vs. Year Ago Period: 59.38% vs. Previous Quarter: -333.33% Sales Growth vs. Year Ago Period: -59.60% vs. Previous Quarter: -61.65% ROE 12/31/25 - - 09/30/25 - -125.91 06/30/25 - -120.27 ROA 12/31/25 - - 09/30/25 - -57.58 06/30/25 - -55.61 Current Ratio 12/31/25 - - 09/30/25 - 3.83 06/30/25 - 3.97 Quick Ratio 12/31/25 - - 09/30/25 - 3.83 06/30/25 - 3.97 Operating Margin 12/31/25 - - 09/30/25 - -108.11 06/30/25 - -110.35 Net Margin 12/31/25 - - 09/30/25 - -108.11 06/30/25 - -110.35 Pre-Tax Margin 12/31/25 - - 09/30/25 - -107.39 06/30/25 - -110.35 Book Value 12/31/25 - - 09/30/25 - 0.47 06/30/25 - 0.59 Inventory Turnover 12/31/25 - - 09/30/25 - - 06/30/25 - - Debt-to-Equity 12/31/25 - - 09/30/25 - 0.00 06/30/25 - 0.00 Debt-to-Capital 12/31/25 - - 09/30/25 - 0.00 06/30/25 - 0.00

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