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Zacks Company Profile for VYNE Therapeutics Inc. (VYNE : NSDQ)

• Company Description    VYNE Therapeutics Inc. focuses on developing and commercializing therapeutics for dermatology. The company's product pipeline consist FMX103 and FCD105 which are in clinical stage. VYNE Therapeutics Inc., formerly known as Menlo Therapeutics Inc., is based in Bridgewater, New Jersey. Number of Employees: 13

• Price / Volume Information    Yesterday's Closing Price: $0.58 Daily Weekly Monthly 20 Day Moving Average: 14,991,179 shares Shares Outstanding: 33.29 (millions) Market Capitalization: $19.31 (millions) Beta: 1.95 52 Week High: $4.30 52 Week Low: $0.28 Short Interest Ratio:   % Price Change % Price Change Relative to S&P 500 4 Week 55.02% 55.29% 12 Week 40.49% 38.23% Year To Date 0.00% 0.00%

• Address & Contact Information Street Address Phone / Fax Email Address Web URL 685 ROUTE 202/206 SUITE 301 - BRIDGEWATER,NJ 08807 USA ph: 800-775-7936 fax: - jfraunces@lifesciadvisors.com http://www.vynetherapeutics.com

• General Corporate Information    Officers David Domzalski - Chief Executive Officer and Director Tyler Zeronda - Chief Financial Officer Sharon Barbari - Director Steven Basta - Director Christine Borowski - Director Peer Information VYNE Therapeutics Inc. (GSAC) VYNE Therapeutics Inc. (CASI) VYNE Therapeutics Inc. (ALCD.) VYNE Therapeutics Inc. (OMNN) VYNE Therapeutics Inc. (CGPI.) VYNE Therapeutics Inc. (CATX) Industry / Sector / Ticker Info Analyst Coverage: No Industry Group: MED-DRUGS Sector: Medical CUSIP: 92941V308 SIC: 2834 Fiscal Year Fiscal Year End: December Last Reported Quarter: 09/01/25 Next Expected EPS Date: 03/05/26 Share - Related Items Shares Outstanding: 33.29 Most Recent Split Date: 2.00 (0.06:1) Beta: 1.95 Market Capitalization: $19.31 (millions)

• EPS Information     • Dividend Information Analyst Coverage: No Dividend Yield: 0.00% Current Fiscal Quarter EPS Consensus Estimate: $-0.20 Indicated Annual Dividend: $0.00 Current Fiscal Year EPS Consensus Estimate: $-0.85 Payout Ratio: Number of Estimates in the Fiscal Year Consensus: 2.00 Change In Payout Ratio: Estmated Long-Term EPS Growth Rate: % Last Dividend Paid: NA - $0.00 Next EPS Report Date: 03/05/26

• Fundamental Ratios P/E Current FY Estimate: - Trailing 12 Months: - PEG Ratio: - Price Ratios Price/Book: 0.60 Price/Cash Flow: - Price / Sales: 36.85 EPS Growth vs. Year Ago Period: 41.38% vs. Previous Quarter: -30.77% Sales Growth vs. Year Ago Period: 39.67% vs. Previous Quarter: 144.93% ROE 12/31/25 - - 09/30/25 - -80.84 06/30/25 - -77.57 ROA 12/31/25 - - 09/30/25 - -66.20 06/30/25 - -63.09 Current Ratio 12/31/25 - - 09/30/25 - 8.87 06/30/25 - 7.60 Quick Ratio 12/31/25 - - 09/30/25 - 8.87 06/30/25 - 7.60 Operating Margin 12/31/25 - - 09/30/25 - -6,448.47 06/30/25 - -8,092.65 Net Margin 12/31/25 - - 09/30/25 - -6,425.19 06/30/25 - -8,097.69 Pre-Tax Margin 12/31/25 - - 09/30/25 - -6,447.71 06/30/25 - -8,091.81 Book Value 12/31/25 - - 09/30/25 - 0.97 06/30/25 - 1.97 Inventory Turnover 12/31/25 - - 09/30/25 - - 06/30/25 - - Debt-to-Equity 12/31/25 - - 09/30/25 - 0.00 06/30/25 - 0.00 Debt-to-Capital 12/31/25 - - 09/30/25 - 0.00 06/30/25 - 0.00

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